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For each study, the following information was collected: last name of the first author, publication year, study design and ethnicity, age, PSA, sample size and the values of true positive (TP false positive (FP false negative (FN true. Diagnosis, tests are used to screen for different types of cancer. 10.4049/jimmunol.0802740 PMC free article PubMed CrossRef Google Scholar. There was a high degree of heterogeneity in sensitivity (2 271.39, P .001 specificity (2 735.87, P .001 and diagnostic OR (Cochran-Q 137.22, P .001 consequently, the diagnostic indices were calculated using a random effects model. 2015;193: e817.1016/j.juro.2015.02.2358 CrossRef Google Scholar. Then, the reference sections of the identified publications were searched to identify additional potentially relevant articles. In 1999, Bussemakers.